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Vol. 18 No. 2 (2019)
Original Articles

Racial/ethnic differences in bone mineral density, muscle function and fat mass in young women

Japneet Kaur
Department of Health and Exercise Science. University of Oklahoma, Norman, Oklahoma, USA.
Ryan Miller
Department of Health and Exercise Science. University of Oklahoma, Norman, Oklahoma, USA.
Eduardo Freitas
Department of Health and Exercise Science. University of Oklahoma, Norman, Oklahoma, USA.
Debra Bemben
Department of Health and Exercise Science. University of Oklahoma, Norman, Oklahoma, USA.
Michael Bemben
Department of Health and Exercise Science. University of Oklahoma, Norman, Oklahoma, USA.
DOI:

Published 2020-01-03

Keywords

  • DXA,
  • Osteoporosis,
  • Body composition,
  • Premenopausal,
  • Lean mass,
  • Muscle strength
  • ...More
    Less

How to Cite

1.
Japneet Kaur, Ryan Miller, Eduardo Freitas, Debra Bemben, Michael Bemben. Racial/ethnic differences in bone mineral density, muscle function and fat mass in young women. BJHBS [Internet]. 2020 Jan. 3 [cited 2024 Oct. 12];18(2):103-1. Available from: /bjhbs/article/view/119
Crossref
Scopus

Abstract

Background: Racial/ethnic differences in bone mineral density (BMD) result in increased susceptibility of some ethnic groups to fragility fractures in comparison to others. Conventionally, both lean mass and fat mass provide mechanical loading to the skeleton and increase BMD, however, increase in fat mass beyond a certain level without a concurrent increase in muscle mass/strength, is detrimental to the skeleton. The aim of this study was to determine racial/ethnic differences in BMD, muscle function and fat mass in 18-30-year-old women of Caucasian, East-Asian, South-Asian, Hispanic and African-American backgrounds. Materials and methods: Forty-six women participated in the study. The visits included signing a written informed consent and questionnaires to assess health status, menstrual history, physical activity and calcium intake. Body composition (fat mass, bone free lean body mass (BFLBM), and bone mineral content (BMC)) and total and regional BMD were measured using Dual Energy X-Ray Absorptiometry, while handgrip test, jump test, 1Repetition-Maximum leg press test, and bilateral isokinetic testing of knee flexors and extensors were used to quantify lower limb muscle strength and power. Results: African-American women had a higher BMD at the left and right trochanter (p=0.03) and higher BMC at several sites in comparison to South-Asians (p=0.02) and Hispanics (p=0.03). South-Asian women had a higher fat mass (p=0.04) and percent body fat (p=0.003), and lower BFLBM (p=0.04) and strength (p=0.003) than East-Asians and Caucasians. Conclusion: This type of research is essential to identify at-risk minorities and fundamental for creating awareness, developing ethnicity-specific diagnostic criteria, and preventative and therapeutic strategies.

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References

  1. Berenson AB, Breikopf CR, Newman JL, et al. Contribution of fat free mass to bone mineral density among reproductive-aged women of black, white and Hispanic race/ethnicity. J Clin Densitom. 2009;12(2):200-206.
  2. Burge R, Dawson-Hughes B, Solomon DH, et al. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007;22(3):465-475.
  3. Pothiwala P, Evans EM, Chapman-Novakofski KM. Ethnic variations in risk for osteoporosis for women: a review of biological and behavioral factors. J Women’s Health. 2006;15(6):709-719.
  4. Chen Z, Qi L, Beck TJ, et al. Stronger bone correlates with African admixture in African-American women. J Bone Miner Res. 2011;26(9):2307-2316.
  5. Conradie M, Conradie MM, Kidd M, et al. Bone density in black and white South African women: contribution of ethnicity, body weight and lifestyle. Arch Osteoporos. 2014;9:193.
  6. Finkelstein JS, Lee MT, Sowers M, et al. Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab. 2002;87(7):3057-67.
  7. Leslie WD. Ethnic differences in bone mass- Clinical Implications. J Clin Endocrinol Metab. 2012;97(12):4329-40. doi: 10.1210/jc.2012-2863
  8. Barrett-Connor E, Siris ES, Wehren LE, et al. Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res. 2005;20(2):185-94.
  9. Cong E, Walker MD. The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture. Bone Res. 2014;2:14009.
  10. Silverman SL, Madison RE. Decreased incidence of hip fracture in Hispanics, Asians, and blacks: California Hospital Discharge Data. Am J Public Health. 1988;78(11):1482-3.
  11. Boutroy S, Walker MD, Liu XS, et al. Lower cortical porosity and higher tissue mineral density in Chinese American versus White women. J Bone Miner Res. 2014;29(3):551-61.
  12. Cheung EYN, Tan KCB, Cheung CL, et al. Osteoporosis in East Asia: Current issues in assessment and management. Osteoporos Sarcopenia. 2016;2(3):118-133. doi.org/10.1016/j. afos.2016.07.001.
  13. Cheung CL, BinAng S, Chadha M, et al. An upated hip fracture projection in Asia: The Asian Federation of Osteoporosis Societies study. Osteoporos Sarcopenia. 2018;16-21. doi. org/10.1016/j.afos.2018.03.003
  14. Lau EM, Lee JK, Suriwongpaisal P, et al. The incidence of hip fracture in four Asian countries: the Asian Osteoporosis Study (AOS). Osteoporos Int. 2001;12(3):239-43.
  15. Khandewal S, Chandra M, Lo JC. Clinical characteristics, bone mineral density and non-vertebral osteoporotic fracture outcomes among post-menopausal U.S. South Asian women. Bone. 2012;51(6):1025-8
  16. Alekel DL, Mortillaro E, Hussain EA, et al. Lifestyle and biologic contributors to proximal femur bone mineral density and hip axis length in two distinct ethnic groups of premenopausal women. Osteoporos Int. 1999;9(4):327-38.
  17. Makker A, Mishra G, Singh BP, et al. Normative bone mineral density at multiple skeletal sites in Indian subjects. Arch Osteoporos. 2008;3:25-37.
  18. Mithal A, Bansal B, Kyer CS, et al. The Asia-Pacific Regional Audit-Epidemiology, Costs, and Burden of Osteoporosis in India 2013: A report of International Osteoporosis Foundation. Indian J Endocrinol Metab. 2014;18(4):449–454.doi: 10.4103/2230-8210.137485
  19. Lu J, Shin Y, Yen MS, et al. Peak bone mass and patterns of change in total bone mineral density and bone mineral contents from childhood into young adulthood. J Clin Densitom. 2016;19(2):180–191.
  20. Heaney RP, Abrams S, Dawson-Hughes B, et al. Peak bone mass. Osteoporos Int. 2000;11:985–1009.
  21. Hughes JM, Petit MA. Biological underpinnings of Frost’s mechanostat thresholds: The important role of osteocytes. J Musculoskelet Neuronal Interact. 2010;10(2):128-135.
  22. Ormsbee MJ, Prado CM, Ilich JZ, et al. Osteosarcopenic obesity: the role of bone, muscle and fat on health. J Cachexia Sarcopenia Muscle. 2014;5:183-192.
  23. Ilich JZ, Kelly OJ, Inglis JE, et al. Interrelationship among muscle, fat and bone: Connecting the dots on cellular, hormonal, and whole body levels. Ageing Res Rev. 2014;15:51-60.
  24. Musgrave KO, Giambalvo L, Leclerc HL, et al. Validation of a quantitative food frequency questionnaire for rapid assessment of dietary calcium intake. J Am Diet Assoc. 1989;89(10):1484– 1488.
  25. Craig CL, Marshall AL, Sjorstrom M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35:1381–1395.
  26. Hagstromer M, Oja P, Sjostrom M. The international physical activity questionnaire (IPAQ): A study of concurrent and construct validity. Public Health Nutr. 2006;9:755–762.
  27. Kim SJ, Baker BS, Sharma-Ghimire P, et al. Association between bone-specific physical activity scores and pQCT-derived measures of bone strength and geometry in healthy young and middle-aged premenopausal women. Arch Osteoporos. 2018;13(1):83. doi: 10.1007/s11657-018-0495-8
  28. Singh H, Kim D, Bemben MG, et al. Relationship between muscle performance and DXA-derived bone parameters in community-dwelling older adults. J Musculoskelet Neuronal Interact. 2017;17(2):50-58.
  29. Gába A, Kapuš O, Pelclová J, et al. The relationship between accelerometer-determined physical activity (PA) and body composition and bone mineral density (BMD) in postmenopausal women. Arch Gerontol Geriatr. 2012;54(3):e315-21.
  30. Cauley JA, Lui LY, Ensrud KE, et al. Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA. 2005;293(17):2102-2108.
  31. Putman MS, Yu EW, Lee H, et al. Differences in skeletal microarchitecture and strength in African-American and Caucasian women. J Bone Miner Res. 2013;28(10):2177-2185.
  32. Silva AM, Shen W, Heo M, et al. Ethnicity-Related Skeletal Muscle Differences Across the Lifespan. Am J Hum Biol. 2010;22(1):76–82. doi: 10.1002/ajhb.20956
  33. Liang MTC, Bassin S, Dutto D, et al. Bone mineral density and leg muscle strength in young Caucasian, Hispanic and Asian women. J Clin Densitom. 2007;10(2):157–164.
  34. McGrath RP, Kraemer WJ, Vincent BM, et al. Muscle strength is protective against osteoporosis in an ethnically diverse sample of adults. J Strength Cond Res. 2017;31(9):2586-2589.
  35. Suminski RR, Mattern CO, Devor ST. Influence of racial origin and skeletal muscle properties on disease prevalence and physical performance. Sports Med. 2002;32(11):667-673.
  36. Vasquez E, Shaw BA, Gensburg L, et al. Racial and ethnic differences in physical activity and bone density: National Health and Nutrition Examination Survey, 2007-2008. Prev Chronic Dis. 2013;10:E216.
  37. Avin KG, Bloomfield SA, Gross TS, et al. Biomechanical aspects of the muscle-bone interaction. Curr Osteoporos Rep. 2015;13(1):1-8. doi: 10.1007/s11914-014-0244-x
  38. Ranasinghe CD, Ranasinghe P, Jayawardena R, et al. Physical activity patterns among South Asian adults: a systematic review. Int J Behav Nutr Phys Act. 2013;10:116.
  39. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol. 2006;2(1):35-43.
  40. Stefanaki C, Peppa M, Boschiero D, et al. Healthy overweight/ obese: early osteosarcopenic obesity features. Eur J Clin Invest. 2016;46(9):767-778.