香港六合彩开奖结果

Vol. 21 No. 2 (2022)
Original Articles

The anti-inflammatory effect of propolis on human tissue: A systematic review

DOI:

Published 2023-01-03

Keywords

  • Propolis,
  • Wound healing,
  • Complementary therapies,
  • Anti-inflammatory activity

How to Cite

1.
H. S. B. Junior P, C. C. Farias L, P. Oliveira S, V. Perlingeiro R, C. Henrique S, C. Coelho-Oliveira A, C. S谩-Caputo D, F. Ferreira-Souza L, Bernardo-Filho M. The anti-inflammatory effect of propolis on human tissue: A systematic review. BJHBS [Internet]. 2023 Jan. 3 [cited 2024 Oct. 12];21(2):91-100. Available from: /bjhbs/article/view/3
Crossref
Scopus

Abstract

Introduction: The healing process that occurs after a tissue lesion聽is divided into three distinct phases: inflammation phase,聽proliferation, and remodeling. Despite the structural similarity聽of the anatomy of the skin and oral mucosa, the oral mucosa聽presents a unique healing environment. Treatment options for聽chronic lesions are still limited, hence efforts in the research of聽traditional therapies with alternative clinical treatments, such聽as the use of propolis, have been conducted. Objectives: This聽systematic review aims to evaluate the anti-inflammatory聽property of propolis in the tissue repair process. Methods: A database聽search was performed using the descriptors 鈥淧ropolis鈥,聽鈥淲ound Healing鈥 and 鈥淐omplementary Therapies鈥. Results:聽Ninety-three publications were found in electronic databases.聽Of these 93 articles, 84 were excluded for failing to meet the聽eligibility criteria and only 9 articles were read in full. With聽regard to design, seven works were considered to be of 鈥渇air鈥澛爉ethodological quality and two considered to be 鈥減oor鈥.聽Only one study was classified as Level of evidence III-2, three聽studies as III-3, and five studies as IV, due to the studies having聽been carried out without specific interventions. Conclusions:聽The benefits of propolis can be considered to be its proven聽anti-inflammatory activity, as well as collagen stimulation,聽rapid promotion of the healing process, and few side effects.

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References

  1. Zeng R, Lin C, Lin Z, et al. Approaches to cutaneous wound healing: basics and future directions. Cell Tissue Res. 2018;374(2):217-232. doi:10.1007/s00441-018-2830-1.
  2. Gurtner GC, Werner S, Barrandon Y, et al. Wound repair and regeneration. Nature. 2008;453(7193):314-321. doi:10.1038/nature07039.
  3. Astrada A, Nakagami G, Jais S, et al. Successful treatment of a diabetic foot ulcer with exposed bone using Trigona honey: a case study. J Wound Care. 2019;28(Sup12):S4-S8. doi:10.12968/jowc.2019.28.Sup12.S4.
  4. Al-Irayfawee NSH, Al-Biatey DKA, Al-Mubarak ZAH. Effectiveness of Punica Granatum and Propolis: A New Dressing Method in Management of Diabetic Foot Ulceration. Indian Journal of Forensic Medicine & Toxicology [Internet]. 2019 Feb.8 13(1):314-20. Available from: .
  5. Eslami H, Motahari P, Safari E, et al. Evaluation effect of low-level Helium-Neon laser and Iranian propolis extract on Collagen Type I gene expression by human gingival fibroblasts: an in vitro study. Laser Ther. 2017;26(2):105-112. doi:10.5978/islsm.17-OR-8.
  6. Limandjaja GC, Niessen FB, Scheper RJ, et al. The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models. Front Cell Dev Biol. 2020;8:360. 2020. doi:10.3389/fcell.2020.00360.
  7. Evans EW. Treating Scars on the Oral Mucosa. Facial Plast Surg Clin North Am. 2017;25(1):89-97. doi:10.1016/j.fsc.2016.08.008.
  8. Iglesias-Bartolome R, Uchiyama A, Molinolo AA, et al. Transcriptional signature primes human oral mucosa for rapid wound healing. Sci Transl Med. 2018;10(451):eaap8798. doi:10.1126/scitranslmed.aap8798.
  9. Shin JW, Kwon SH, Choi JY, et al. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int J Mol Sci. 2019;20(9):2126. 2019. doi:10.3390/ijms20092126.
  10. Ishida T, Takeuchi K, Hayashi S, et al. Anatomical structure of the subcutaneous tissue on the anterior surface of human thigh. Okajimas Folia Anat Jpn. 2015;92(1):1-6. doi:10.2535/ofaj.92.1.
  11. Hotz B, Visekruna A, Buhr HJ, et al. Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing. J Gastrointest Surg. 2010;14(2):388-397. doi:10.1007/s11605-009-1068-3.
  12. Wang X, Qian Y, Jin R, et al. Effects of the trap-1 protein gene on collagen synthesis induced by tgf-beta/smad signaling in human dermal fibroblasts. PLoS One. 2013;8:e55899. doi:10.1371/journal.pone.0055899.
  13. Diegelmann RF, Evans MC. Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci. 2004;9:283-289. 2004. doi:10.2741/1184.
  14. Tredget EB, Demare J, Chandran G, et al. Transforming beta-growth factor and its effect on the reefielialization of partially thick ear wounds in transgenic rats. Wound repair 2005;13:61-67. doi:10.1111/j.1067-1927.2005.130108.x.
  15. Pereira RF, B谩rtolo PJ. Traditional Therapies for Skin Wound Healing. Adv Wound Care. 2016;5(5):208-229. doi:10.1089/wound.2013.0506.
  16. Alt谋parmak M, et al. 鈥淗ealing properties of skin wounds of hypericum perforatum, liquidambar orientalis and propolis mixtures.鈥 European Journal of Plastic Surgery. 42.5 (2019): 489-494. doi.org/10.1007/s00238-019-01538-6.
  17. Nani M, Leone A, Bom VP, et al. Evaluation and Comparison of Wound Healing Properties of an Ointment (AlpaWash) Containing Brazilian Micronized Propolis and Peucedanum ostruthium Leaf Extract in Skin Ulcer in Rats. Int J Pharm Compd. 2018;22(2):154-163.
  18. U莽ar M, De臒er O. Evaluation of cytotoxic and wound healing effect of Turkish propolis DMEM extracts on MDA-MB-231 cell lines. Tropical Journal of Pharmaceutical Research 18.2 (2019): 321-325. doi:10.4314/tjpr.v18i2.14.
  19. Zohery AA, Meshri SM, Madi MI, et al. Egyptian propolis compared to nanohydroxyapatite graft in the treatment of Class II furcation defects in dogs. Journal of Periodontology. 2018 Nov;89(11):1340-1350. doi: 10.1002/jper.17-0685.
  20. Burdock GA. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol. 1998;36(4):347-363. doi:10.1016/s0278-6915(97)00145-2.
  21. Wagh VD. Propolis: a wonder bees product and its pharmacological potentials. Adv Pharmacol Sci. 2013;2013:308249. doi:10.1155/2013/308249.
  22. Vagish Kumar, LS. Propolis in dentistry and oral cancer management. N Am J Med Sci. 2014;6(6):250-259. doi:10.4103/1947-2714.134369.
  23. Saral 脰, Yildiz O, Aliyazicio臒lu R, et al. Apitherapy products enhance the recovery of CCL4-induced hepatic damages in rats. Turk J Med Sci. 2016;46(1):194-202. doi:10.3906/sag-1411-35.
  24. Hozzein WN, Badr G, Al Ghamdi AA, et al. Topical application of propolis enhances cutaneous wound healing by promoting TGF-beta/Smad-mediated collagen production in a streptozotocin-induced type I diabetic mouse model. Cell Physiol Biochem. 2015;37(3):940-954. doi:10.1159/000430221.
  25. Santos CMC, Pimenta CAM, Nobre MR. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem. 2007;15(3):508-511. doi:10.1590/s0104-11692007000300023.
  26. Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. doi:10.1186/2046-4053-4-1.
  27. Zaugg H, West RE, Tateishi I, et al. Mendeley: Creating communities of scholarly inquiry through research collaboration. TechTrends. 2011;55(1), 32-36. doi.10.1007/s11528-011-0467-y.
  28. Shiwa SR, Costa LOP, Moser ADL, et al. PEDro: a base de dados de evid锚ncias em fisioterapia. Fisioterapia em Movimento, [S.l.], v. 24, n. 3, set. 2017. ISSN 1980-5918. Available in: . doi.org/10.1590/S0103-51502011000300017.
  29. Merlin T, Weston A, Tooher R. Extending an evidence hierarchy to include topics other than treatment: Revising the Australian 鈥渓evels of evidence.鈥 BMC Med Res Methodol. 2009; 9(1):34. doi.org/10.1186/1471-2288-9-34.
  30. Cao XP, Chen YF, Zhang JL, et al. Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity. Phytomedicine. 2017;34:76-84. doi:10.1016/j.phymed.2017.06.001.
  31. Al Jadi A, Youssef K. Isolation and identification of phenolic acids in Malaysian honey with antibacterial properties. Turk J Med Sci 2003; 33: 229鈥236.
  32. Cui K, Lu W, Zhu L, et al. Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity. Biochem Biophys Res Commun. 2013;435(2):289-294. doi:10.1016/j.bbrc.2013.04.026.
  33. Hegazi AG. Medical importance of bee products. U Bee J. 2012;12: 136鈥146.