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Vol. 20 No. 2 (2021)
Literature Review

Leprosy: A clinical review

DOI:

Published 2022-01-04

Keywords

  • Mycobacterium leprae,
  • Leprosy,
  • Epidemiology

How to Cite

1.
P. Gomes A, B. Miguel PS, B. Martins e Mafra F, L. de Moura AC, M. Braga L. Leprosy: A clinical review. BJHBS [Internet]. 2022 Jan. 4 [cited 2024 Oct. 12];20(2):151-60. Available from: /bjhbs/article/view/38
Crossref
Scopus

Abstract

Leprosy is a chronic infectious disease, caused by Mycobacterium leprae. It has great historical importance and is responsible for high rates of infected people all over the world, Brazil being the second country in number of cases, only behind India. The clinical manifestations of the disease depend on the host鈥檚 immune response, and it has the potential to affect practically all organs and systems, although it mainly affects the skin and peripheral nerves, and may, above all, present periods of aggra-vation, which are called reactions. Thus, it is characterized as a disease of incapacitating character, which can bring irreparable physical deformities, presenting a great impact on the physical, social, and mental health of the patient. In this review we discuss the main aspects involving the condition of neglected disease, especially the epidemiology, classifications, clinical picture, complications, diagnosis, treatment, and care for prevention.

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References

  1. Hess S, Rambukkana A. Cell biology of intracellular adaptation of Mycobacterium leprae in the peripheral nervous system. Bacteria and Intracellularity. 2020:227-245. .
  2. Arif T, Dorjay K, Adil M, et al. Classification of leprosy- From past to present. Journal of Pakistan Association of Dermatology. 2018; 28(1):95-99.
  3. Sarode G, Sarode S, Anand R, et al. Epidemiological aspects of leprosy. Disease-a-Month, 2020: 100899.
  4. Ti贸-Coma M, Wijnands T, Pierneef L, et al. Detection of Mycobacterium leprae DNA in soil: multiple needles in the haystack. Scientific reports. 2019;9(1):1-7. https://doi. org/10.1038/s41598-019-39746-6
  5. Steinmann P, Dusenbury C, Addiss D, et al. A comprehensive research agenda for zero leprosy. Infectious Diseases of Poverty. 2020;9(1):1-7. .
  6. Pedelacq JD, Nguyen MC, Terwilliger TC, et al. A Comprehensive Review on Mycobacterium tuberculosis Targets and Drug Development from a Structural Perspective. Structural Biology in Drug Discovery: Methods, Techniques, and Practices. 2020:545-566. DOI: 10.1002/9781118681121.ch23
  7. Maymone MB, Laughter M, Venkatesh S, et al. Leprosy: Clinical Aspects and Diagnostic Techniques. Journal of the American Academy of Dermatology. 2020;83:1-13. https://doi. org/10.1016/j.jaad.2019.12.080
  8. Shepard CC. The experimental disease that follows the injection of human leprosy bacilli into footpads of mice. Journal of Experimental Medicine. 1960;112(3):445鈥54. https://doi. org/10.1084/jem.112.3.445
  9. Sharma R, Singh P, McCoy RC, et al. Isolation of Mycobacterium lepromatosis and Development of Molecular Diagnostic Assays to Distinguish Mycobacterium leprae and M. lepromatosis. Clinical Infectious Diseases. 2020;71(8):e262-e269.
  10. Avanzi C, Singh P, Truman RW, et al. Molecular epidemiology of leprosy: An update. Infection, Genetics and Evolution, 2020:104581.
  11. Bhandari J, Awais M, Gupta V. Leprosy (Hansen Disease). StatPearls [Internet]. 2020. Available from:
  12. Reibel F, Cambau E, Aubry A. Update on the epidemiology, diagnosis, and treatment of leprosy. Med Mal Infect. 2015;45:383-93.
  13. Grayson, W. An update on cutaneous infections. Diagnostic Histopathology. 2020;26(3):107-113.
  14. Mathema B, Kurepina NE, Bifani PJ, et al. Molecular epidemiology of tuberculosis: current insights. Clinical microbiology reviews. 2006;19(4), 658-685.
  15. Das M, Diana D, Wedderburn A, et al. Molecular epidemiology and transmission dynamics of leprosy among multicase families and case-contact pairs. International Journal of Infectious Diseases. 2020;96:172-179.
  16. Brasil. Minist茅rio da Sa煤de. Guia de Vigil芒ncia em Sa煤de 3. ed. Bras铆lia. 2019; p 294-325.
  17. White C, Franco-Paredes C. Leprosy in the 21st century. Clinical Microbiology Reviews. 2015;28(1):80-94.
  18. Truman R, Singh P, Sharma R, et al. Probable Zoonotic Leprosy in the Southern United States. N Engl J. Med. 2011;364:1626鈥1633. DOI: 10.1128/CMR.00079-13
  19. Chavarro-Portillo B, Soto CY, Guerrero MI. Mycobacterium leprae鈥檚 evolution and environmental adaptation. Acta Tropica. 2019;197:105041. . actatropica.2019.105041.
  20. Bratschi MW, Steinmann P, Wickenden A, et al. Current knowledge on Mycobacterium leprae transmission: a systematic literature review. Leprosy Review. 2015;86(2):142-55.
  21. World Health Organization. Global Leprosy Strategy 2016-2020: Accelerating towards a world without leprosy. Geneva: WHO/SEARO, 2016. 36 p.
  22. World Health Organization. Weekly epidemiological record. 2019 30 Aug; 94(35/36):389:412.
  23. Benjak A, Avanzi C, Benito Y, et al. Highly reduced genome of the new species Mycobacterium uberis, the causative agent of nodular thelitis and tuberculoid scrotitis in livestock and a close relative of the leprosy bacilli. MSphere. 2018;3(5):1-11. 10.1128/mSphere.00405-18
  24. Lyon S, Grossi MAF. Leprosy. Rio de Janeiro: Medbook, 2013.
  25. Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five group system. International Journal of Leprosy. 1966;34:255-273.
  26. Last贸ria JC, Abreu MAMMD. Leprosy: review of the epidemiological, clinical, and etiopathogenic aspects-part 1. Anais Brasileiros de Dermatologia. 2014;89(2):205-218.
  27. Brand茫o LSG, Marques GF, Barreto JA, et al. Tuberculoid leprosy presenting as a 鈥渞acket鈥 lesion. Anais Brasileiros de Dermatologia. 2015;90(3):420-422. 10.1590/abd1806-4841.20153401
  28. Rodrigues ACS, Quintella DC, Rodrigues FT, et al. Lepromatous Leprosy: Report of a Case of the Histiocytic-Symile Type. Journal of the Portuguese Society of Dermatology and Venereology. 2019;77(1):73-76.
  29. Kumar B, Uprety S, Dogra S. Clinical diagnosis of leprosy. International Textbook of Leprosy. 2017. 24p. Dispon铆vel em:
  30. World Health Organization. Expert committee on leprosy. World Health Organ Tech Rep Ser. 1998;874:1-43.
  31. Santos DFD, Mendon莽a MR, Antunes DE, et al. Revisiting primary neural leprosy: clinical, serological, molecular, and neurophysiological aspects. PLoS Negl Trop Dis. 2017;11(11):e0006086.
  32. Freitas RCSD, Pereira CAZ, Muri NT, et al. Primary neural leprosy mimicking rheumatological disorders. Revista da Associa莽茫o M茅dica Brasileira. 2019;65(6):767-770.
  33. Cohens JM. Hansen铆ase ocular: uma abordagem hist贸rica. Arquivos Brasileiros de Oftalmologia. 2009;72(5):728-33.
  34. Ara煤jo AERA, Aquino DMC, Goulart IMB, et al. Complica莽玫es neurais e incapacidades em hansen铆ase em capital do nordeste brasileiro com alta endemicidade. Revista Brasileira de Epidemiologia. 2014;17(4):899-910. https://doi. org/10.1590/1809-4503201400040009
  35. Azulay RD, Azulay DR, Azulay-Abulafia L. Dermatology. Rio de Janeiro: Ed. 2017.
  36. Antunes DE, Goulart IMB, Goulart LR. Will cases of leprosy reaction increase with COVID-19 infection. PLoS neglected tropical diseases. 2020;14(7), e0008460.
  37. Akpolat ND, Akkus A, Kaynak E. An update on the epidemiology, diagnosis and treatment of leprosy. In: Hansen鈥檚 Disease-The Forgotten and Neglected Disease. IntechOpen, 2018. Dispon铆vel em: .
  38. Brasil. Minist茅rio da Sa煤de. Guia Pr谩tico em hansen铆ase. 1. ed. Bras铆lia, 2017.
  39. World Health Organization. Weekly Epidemiological Record. 2021;96:01-02.
  40. Lyon S, Grossi, MAF. Diagnosis and treatment of leprosy. In: Leprosy advances and challenges. 2014; p.141-169.
  41. Narang T, Bishnoi A, Dogra S, et al. Alternate Anti-Leprosy Regimen for Multidrug Therapy Refractory Leprosy: A Retrospective Study from a Tertiary Care Center in North India, The American Journal of Tropical Medicine and Hygiene. 2019;100(1):24-30.
  42. Brasil. Coordena莽茫o de Monitoramento e Avalia莽茫o de Tecnologias em Sa煤de 鈥 CMATS/CGGTS/DGITIS/SCTIE/MS. Relat贸rio de recomenda莽茫o de medicamento no. 583. Amplia莽茫o de uso da claritromicina para o tratamento de pacientes com hansen铆ase resistente a medicamentos. Bras铆lia, 2020.
  43. Bhandari J, Awais M, Robbins BA, et al. Leprosy. [Updated 2021 Jun 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www. ncbi.nlm.nih.gov/books/NBK559307/
  44. Sarkar T, Sarkar S, Patra AC, et al. BCG vaccination: Effects on the patterns of pediatric leprosy. J Family Med Prim Care. 2020 Jul 30;9(7):3673-3676.
  45. Smith CM, Smith WC. Chemoprophylaxis is effective in the prevention of leprosy in endemic countries: a systematic review and meta-analysis. MILEP2 Study Group. Mucosal Immunology of Leprosy. Journal of Infect. 2000;41(2):137-42. https://doi. org/10.1053/jinf.2000.0698.
  46. Schoenmakers A, Mieras L, Budiawan T, et al. The State of Affairs in Post-Exposure Leprosy Prevention: A Descriptive Meta-Analysis on Immuno- and Chemo-Prophylaxis. Res Rep Trop Med. 2020;11:97-117.
  47. Richardus R, Alam K, Kundu K, et al. Effectiveness of single-dose rifampicin after BCG vaccination to prevent leprosy in close contacts of patients with newly diagnosed leprosy: A cluster randomized controlled trial. Int J Infect Dis. 2019 Nov;88:65-72. .
  48. Setia MS, Steinmaus C, Ho CS, et al. The role of BCG in prevention of leprosy: a meta-analysis. Lancet Infectious Diseases. 2006;6(3):162-70. DOI:
  49. Mungroo MR, Khan NA, Siddiqui R. Mycobacterium leprae: Pathogenesis, diagnosis, and treatment options. Microbial Pathogenesis. 2020;104475. . micpath.2020.104475