@article{Daniela C. Andrade_Nascimento_P. de Oliveira_Freire_Simone N. de Carvalho_Ana Carolina Stumbo_La铆s Carvalho_Alessandra A. Thole_Erika Cortez_2023, place={Rio de Janeiro - RJ, Brazil}, title={Insulin-like growth factor-1 short-period therapy improves Non-Alcoholic Fatty Liver Disease (NAFLD) in obese mice}, volume={22}, url={/bjhbs/article/view/151}, DOI={10.12957/bjhbs.2023.79959}, abstractNote={<p><span class="TextRun SCXW227868565 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW227868565 BCX0">T</span><span class="NormalTextRun SCXW227868565 BCX0">h</span><span class="NormalTextRun SCXW227868565 BCX0">is </span><span class="NormalTextRun SCXW227868565 BCX0">study </span><span class="NormalTextRun SCXW227868565 BCX0">seeks </span><span class="NormalTextRun SCXW227868565 BCX0">to evaluate </span><span class="NormalTextRun SCXW227868565 BCX0">I</span><span class="NormalTextRun SCXW227868565 BCX0">nsulin-like Growth Factor 1</span><span class="NormalTextRun SCXW227868565 BCX0"> (IGF-1)</span> <span class="NormalTextRun SCXW227868565 BCX0">short-period therapy in </span><span class="NormalTextRun SCXW227868565 BCX0">Non-Alcoholic Fatty Liver Disease </span><span class="NormalTextRun SCXW227868565 BCX0">(</span><span class="NormalTextRun SCXW227868565 BCX0">NAFLD</span><span class="NormalTextRun SCXW227868565 BCX0">)</span> <span class="NormalTextRun SCXW227868565 BCX0">as it </span><span class="NormalTextRun SCXW227868565 BCX0">relate</span><span class="NormalTextRun SCXW227868565 BCX0">s</span><span class="NormalTextRun SCXW227868565 BCX0"> to </span><span class="NormalTextRun SCXW227868565 BCX0">w</span><span class="NormalTextRun SCXW227868565 BCX0">estern diet-induced obesity. For this purpose, 21-day-old male Swiss mice were divided into </span><span class="NormalTextRun SCXW227868565 BCX0">a </span><span class="NormalTextRun SCXW227868565 BCX0">control group (CG, N=8), </span><span class="NormalTextRun SCXW227868565 BCX0">which was </span><span class="NormalTextRun SCXW227868565 BCX0">fed a standard diet, and </span><span class="NormalTextRun SCXW227868565 BCX0">an </span><span class="NormalTextRun SCXW227868565 BCX0">obese group (GO, N=16), </span><span class="NormalTextRun SCXW227868565 BCX0">which was </span><span class="NormalTextRun SCXW227868565 BCX0">fed a </span><span class="NormalTextRun SCXW227868565 BCX0">w</span><span class="NormalTextRun SCXW227868565 BCX0">estern diet, rich in saturated fat and simple carbohydrates, for 12 weeks. In the 11th week, part of the animals in the obese group (N=8) received a daily subcutaneous injection of recombinant human IGF-1 (100碌g/kg/day) </span><span class="NormalTextRun SCXW227868565 BCX0">during </span><span class="NormalTextRun SCXW227868565 BCX0">seven consecutive days (GO+IGF-1). </span><span class="NormalTextRun SCXW227868565 BCX0">Biometric and metabolic parameters, intraperitoneal glucose tolerance test (IGTT), quantitative analysis of liver steatosis, quantitative analysis of collagen in liver and expression of immunoperoxidase of alpha-smooth muscle actin (a-SMA) were </span><span class="NormalTextRun SCXW227868565 BCX0">analyzed</span><span class="NormalTextRun SCXW227868565 BCX0">. </span><span class="NormalTextRun SCXW227868565 BCX0">Our data demonstrated that </span><span class="NormalTextRun SCXW227868565 BCX0">IGF-1 short-term </span><span class="NormalTextRun SCXW227868565 BCX0">treatment was able to improve obesity-related biometric and metabolic parameters. In addition, it promoted the recovery of liver parenchyma, </span><span class="NormalTextRun SCXW227868565 BCX0">thereby </span><span class="NormalTextRun SCXW227868565 BCX0">reducing steatosis and fibrosis, thus demonstrating an important hepatoprotective action</span><span class="NormalTextRun SCXW227868565 BCX0">.</span></span><span class="EOP SCXW227868565 BCX0" data-ccp-props="{"201341983":0,"335551550":6,"335551620":6,"335559737":-3,"335559739":0,"335559740":360}"> </span></p>}, number={2}, journal={香港六合彩开奖结果}, author={Daniela C. Andrade and Nascimento, Filipe Jorge and P. de Oliveira, Genilza and Freire, Thiago and Simone N. de Carvalho and Ana Carolina Stumbo and La铆s Carvalho and Alessandra A. Thole and Erika Cortez}, year={2023}, month={Dec.} }