@article{Isabela G. Bristotte_Natália V. S. Daniel_Luciana Pietro_2023, place={Rio de Janeiro - RJ, Brazil}, title={Prevalence of vitamin D deficiency in children with sickle cell anemia: a systematic review}, volume={22}, url={/bjhbs/article/view/153}, DOI={10.12957/bjhbs.2023.80047}, abstractNote={<p><span class="TextRun SCXW222966409 BCX0" lang="EN-US" xml:lang="EN-US" data-contrast="auto"><span class="NormalTextRun SCXW222966409 BCX0">Sickle cell anemia is a </span><span class="NormalTextRun SCXW222966409 BCX0">genetic disease </span><span class="NormalTextRun SCXW222966409 BCX0">that is </span><span class="NormalTextRun SCXW222966409 BCX0">highly prevalent in the Brazilian population, </span><span class="NormalTextRun SCXW222966409 BCX0">especially</span><span class="NormalTextRun SCXW222966409 BCX0"> among</span><span class="NormalTextRun SCXW222966409 BCX0"> black ethnic groups </span><span class="NormalTextRun SCXW222966409 BCX0">descended </span><span class="NormalTextRun SCXW222966409 BCX0">from migration</span><span class="NormalTextRun SCXW222966409 BCX0"> of enslaved people from Africa</span><span class="NormalTextRun SCXW222966409 BCX0">, as well as </span><span class="NormalTextRun SCXW222966409 BCX0">descendants </span><span class="NormalTextRun SCXW222966409 BCX0">from the </span><span class="NormalTextRun SCXW222966409 BCX0">process </span><span class="NormalTextRun SCXW222966409 BCX0">of </span><span class="NormalTextRun SCXW222966409 BCX0">miscegenation. </span><span class="NormalTextRun SCXW222966409 BCX0">The</span><span class="NormalTextRun SCXW222966409 BCX0"> disease </span><span class="NormalTextRun SCXW222966409 BCX0">is a</span> <span class="NormalTextRun SCXW222966409 BCX0">clinical expression of the homozygosity of the hemoglobin S gene, which may be </span><span class="NormalTextRun SCXW222966409 BCX0">of</span><span class="NormalTextRun SCXW222966409 BCX0"> genetic and/or hereditary </span><span class="NormalTextRun SCXW222966409 BCX0">origin</span><span class="NormalTextRun SCXW222966409 BCX0">, </span><span class="NormalTextRun SCXW222966409 BCX0">and is </span><span class="NormalTextRun SCXW222966409 BCX0">caused by the replacement of the normal residue of glutamic acid </span><span class="NormalTextRun SCXW222966409 BCX0">with</span> <span class="NormalTextRun SCXW222966409 BCX0">the amino acid valine in the sixth position of the polypeptide chains of the beta-globin protein</span><span class="NormalTextRun SCXW222966409 BCX0">. This process </span><span class="NormalTextRun SCXW222966409 BCX0">generat</span><span class="NormalTextRun SCXW222966409 BCX0">es </span><span class="NormalTextRun SCXW222966409 BCX0">biochemical alteration</span><span class="NormalTextRun SCXW222966409 BCX0">s</span><span class="NormalTextRun SCXW222966409 BCX0"> in hemoglobin S molecules</span><span class="NormalTextRun SCXW222966409 BCX0"> that </span><span class="NormalTextRun SCXW222966409 BCX0">polymerize inside the erythrocyte and transform into sickle cell</span><span class="NormalTextRun SCXW222966409 BCX0">s</span><span class="NormalTextRun SCXW222966409 BCX0">. </span><span class="NormalTextRun SCXW222966409 BCX0">L</span><span class="NormalTextRun SCXW222966409 BCX0">ack of vitamin D may </span><span class="NormalTextRun SCXW222966409 BCX0">possibly </span><span class="NormalTextRun SCXW222966409 BCX0">be linked to </span><span class="NormalTextRun SCXW222966409 BCX0">disease processes, as well as to individuals</span><span class="NormalTextRun SCXW222966409 BCX0">’</span><span class="NormalTextRun SCXW222966409 BCX0"> pain crises. Objectives: To</span> <span class="NormalTextRun SCXW222966409 BCX0">conduct</span><span class="NormalTextRun SCXW222966409 BCX0"> a systematic review </span><span class="NormalTextRun SCXW222966409 BCX0">in order to </span><span class="NormalTextRun SCXW222966409 BCX0">analyze </span><span class="NormalTextRun SCXW222966409 BCX0">the</span><span class="NormalTextRun SCXW222966409 BCX0"> prevalence of vitamin D deficiency in children with sickle cell anemia. Methodology: A systematic review was carried out by </span><span class="NormalTextRun SCXW222966409 BCX0">means of </span><span class="NormalTextRun SCXW222966409 BCX0">a </span><span class="NormalTextRun SCXW222966409 BCX0">search for original articles </span><span class="NormalTextRun SCXW222966409 BCX0">in the English and Portuguese</span> <span class="NormalTextRun SCXW222966409 BCX0">languages </span><span class="NormalTextRun SCXW222966409 BCX0">in the </span><span class="NormalTextRun SCXW222966409 BCX0">following </span><span class="NormalTextRun SCXW222966409 BCX0">scientific databases: Pubmed, Science Direct, Lilacs and Sciel</span><span class="NormalTextRun SCXW222966409 BCX0">o</span><span class="NormalTextRun SCXW222966409 BCX0">. Results: </span><span class="NormalTextRun SCXW222966409 BCX0">Among</span><span class="NormalTextRun SCXW222966409 BCX0"> 10 articles</span><span class="NormalTextRun SCXW222966409 BCX0"> found</span><span class="NormalTextRun SCXW222966409 BCX0">, 8 showed </span><span class="NormalTextRun SCXW222966409 BCX0">a</span> <span class="NormalTextRun SCXW222966409 BCX0">prevalence of vitamin D deficiency (<20 ng/ml)</span> <span class="NormalTextRun SCXW222966409 BCX0">in children with sickle cell anemia. Conclusion: The prevalence of vitamin D deficiency was high in patients with </span><span class="NormalTextRun SCXW222966409 BCX0">sickle cell</span> <span class="NormalTextRun SCXW222966409 BCX0">disease, so supplementation </span><span class="NormalTextRun SCXW222966409 BCX0">of this substance </span><span class="NormalTextRun SCXW222966409 BCX0">may </span><span class="NormalTextRun SCXW222966409 BCX0">be helpful in</span><span class="NormalTextRun SCXW222966409 BCX0"> treatment</span><span class="NormalTextRun SCXW222966409 BCX0">s</span><span class="NormalTextRun SCXW222966409 BCX0"> to improve the condition and </span><span class="NormalTextRun SCXW222966409 BCX0">in </span><span class="NormalTextRun SCXW222966409 BCX0">prevent</span><span class="NormalTextRun SCXW222966409 BCX0">ing</span><span class="NormalTextRun SCXW222966409 BCX0"> deficiency. However, </span><span class="NormalTextRun SCXW222966409 BCX0">further</span> <span class="NormalTextRun SCXW222966409 BCX0">studies </span><span class="NormalTextRun SCXW222966409 BCX0">that target</span> <span class="NormalTextRun SCXW222966409 BCX0">this association and/or intervention are </span><span class="NormalTextRun SCXW222966409 BCX0">required</span> <span class="NormalTextRun SCXW222966409 BCX0">to </span><span class="NormalTextRun SCXW222966409 BCX0">obtain</span> <span class="NormalTextRun SCXW222966409 BCX0">more </span><span class="NormalTextRun SCXW222966409 BCX0">practical</span> <span class="NormalTextRun SCXW222966409 BCX0">results.</span></span><span class="EOP SCXW222966409 BCX0" data-ccp-props="{"201341983":0,"335551550":6,"335551620":6,"335559739":0,"335559740":360}"> </span></p>}, number={2}, journal={Ïã¸ÛÁùºÏ²Ê¿ª½±½á¹û}, author={Isabela G. Bristotte and Natália V. S. Daniel and Luciana Pietro}, year={2023}, month={Dec.} }