@article{Rezende Correa e Castro Costa_Gomes_Vieira Varej茫o_Will_Tavares_Santana_Siqueira-Batista_2024, place={Rio de Janeiro - RJ, Brazil}, title={Piperacillin-Tazobactam: update for clinical use}, volume={23}, url={/bjhbs/article/view/165}, DOI={10.12957/bjhbs.2024.85197}, abstractNote={<p>Introduction: Piperacillin-tazobactam, a broad-spectrum penicillin, represents a crucial option in the treatment of infections, especially in critically ill patients who exhibit high rates of resistance to various antimicrobial agents. It is of paramount importance to understand this medication and its updates regarding its clinical use to inform precise therapeutic choices aimed at optimizing patient care. Objective: To describe the main pharmacological and therapeutic aspects of piperacillin-tazobactam, highlighting its clinical application and updates related to its use. Methods: A narrative review of the literature was conducted to provide an update on the most relevant aspects related to piperacillin-tazobactam, including (1) a brief history; (2) chemical structure; (3) mechanism of action; (4) resistance mechanisms; (5) spectrum; (6) major clinical uses; and (7) adverse effects. Results: The safe use of piperacillin-tazobactam necessitates rapid testing for antimicrobial resistance patterns, discouraging its empirical use in cases of ESBL-producing microorganisms. In patients undergoing renal replacement therapy, it is crucial to establish antibiotic goals promptly. For critically ill patients, monitoring pharmacodynamic and pharmacokinetic variability is essential. Conclusion: Piperacillin-tazobactam remains a vital drug in the management of critically ill patients, requiring constant updates. Furthermore, there is a need for further studies, especially concerning its continuous use and the selection of alternatives to carbapenem-resistant medications.</p>}, number={1}, journal={香港六合彩开奖结果}, author={Rezende Correa e Castro Costa, Alice and Gomes, Andr茅ia Patr铆cia and Vieira Varej茫o, Eduardo Vin铆cius and Will, Romario Brunes and Tavares, Walter and Santana, Luiz Alberto and Siqueira-Batista, Rodrigo}, year={2024}, month={Aug.} }