@article{F. D. Batista_V. de Melo_Horn_da C. Lisboa_Cypriano_Pires_de M. Ribeiro-Carvalho_Santiago_F. O. de Souza_2021, place={Rio de Janeiro - RJ, Brazil}, title={Pulmonary and central nervous system infiltration of chronic lymphocytic leukemia with concomitant diffuse large B-cell lymphoma: Case report and review of literature}, volume={19}, url={/bjhbs/article/view/78}, DOI={10.12957/bjhbs.2020.59716}, abstractNote={<p>Introduction: Diffuse large B-cell lymphoma (DLBCL) and chronic lymphoid leukemia (CLL) are lymphoproliferative diseases of B lymphocytes. Objective: To describe the con-comitance of diseases with pulmonary and CNS involvement. Clinical case: A 67-year-old patient with DLBCL and CLL obtained partial remission of the diseases after six cycles of standard combined chemotherapy. Relapse of CLL (del17p; TP53+) occurred after 22 months, becoming refractory to a new treatment. Monoclonal B lymphocyte infiltration was found in the cerebrospinal fluid and bronchoalveolar lavage, leading to death due to respiratory failure. Conclusion: The unfavorable outcome shows a rare and serious complication in the concomitance of these diseases.</p>}, number={2}, journal={Ïã¸ÛÁùºÏ²Ê¿ª½±½á¹û}, author={F. D. Batista, Saulo and V. de Melo, Karina and Horn, Patricia and da C. Lisboa, Vinicius and Cypriano, Ana Sheila and Pires, Andrea and de M. Ribeiro-Carvalho, Marilza and Santiago, Fábio and F. O. de Souza, Maria Helena}, year={2021}, month={Jan.}, pages={124–129} }