@article{C. Fernandes_P. Martins_L. F. Medeiros_V. M. Santos_R. M. Gayer_S. M. Velozo_G. P. Coelho_2019, place={Rio de Janeiro - RJ, Brazil}, title={Antinociceptive and anti-inflammatory activities of the hexanic extract of "Echinodorus macrophyllus" (Kunth) Micheli in mice}, volume={18}, url={/bjhbs/article/view/97}, DOI={10.12957/bjhbs.2019.53056}, abstractNote={<p>Introduction: Echinodorus macrophyllus (Kunth) Micheli, Alismataceae, commonly known as “chapéu de couro”, is used in the treatment of various inflammatory conditions. The aim of this study was to evaluate the antinociceptive and anti-inflammatory neurogenic potential and perform the phytochemical analysis of its hexanic extract (HEEm). Mate-rial and methods: The HEEm was obtained by maceration of dried leaves with hexane (100 g d.w./2 L). Its composition was determined by GC-MS (DB1 column) by comparison of reten-tion indices in the database and literature. The antinociceptive potential was evaluated in SW or DBA/1 male mice using chemical (acetic acid and formalin), thermal (tail immersion and hot plate tests) and topical (xylene) nociception models, all approved by the Ethics Committee (CEA-IBRAG). Results: HEEM presented antinociceptive activity in the model of: acetic acid-induced writhing (52%; 25mg/kg); tail immersion (60 and 90 minutes; 50 mg/kg); hot-plate in 60 minutes (25 and 100mg/kg) and 120 minutes (25mg/kg); formalin tests, at the neurogenic (63.4%, 100mg/kg), and inflammatory (50%; 50 and 100mg/kg) phases; and in neurogenic inflammation induced by xylene (88.3%; 100mg/kg). These activities seem to be related to the terpene and fatty acid derivatives evidenced by GC-MS. Discussion: HEEm presented antinociceptive, as well as anti-inflammatory, activity by central and peripheral mechanisms, It consists of terpenic and fatty acid derivatives, described in the literature as antioxidants, anti-inflammatory, and antinociceptives. Conclusions: HEEm showed antinoci-ceptive activity in all models, which can be related to the presence of terpenic and fatty acid derivatives.</p>}, number={1}, journal={������ϲʿ������}, author={C. Fernandes, Daniele and P. Martins, Bruna and L. F. Medeiros, David and V. M. Santos, Shirley and R. M. Gayer, Carlos and S. M. Velozo, Leosvaldo and G. P. Coelho, Marsen}, year={2019}, month={Jul.}, pages={25–32} }