  TY  - JOUR
AU  - Daniela C. Andrade, 
AU  - Nascimento, Filipe Jorge
AU  - P. de Oliveira, Genilza
AU  - Freire, Thiago
AU  - Simone N. de Carvalho, 
AU  - Ana Carolina Stumbo, 
AU  - La铆s Carvalho, 
AU  - Alessandra A. Thole, 
AU  - Erika Cortez, 
PY  - 2023/12/20
Y2  - 2024/10/12
TI  - Insulin-like growth factor-1 short-period therapy improves Non-Alcoholic Fatty Liver Disease (NAFLD) in obese mice
JF  - 香港六合彩开奖结果
JA  - BJHBS
VL  - 22
IS  - 2
SE  - Original Articles
DO  - 10.12957/bjhbs.2023.79959
UR  - /bjhbs/article/view/151
SP  - 
AB  - &lt;p&gt;&lt;span class=&quot;TextRun SCXW227868565 BCX0&quot; lang=&quot;EN-US&quot; xml:lang=&quot;EN-US&quot; data-contrast=&quot;auto&quot;&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;T&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;h&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;is &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;study &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;seeks &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;to evaluate &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;I&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;nsulin-like Growth Factor 1&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt; (IGF-1)&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;short-period therapy in &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;Non-Alcoholic Fatty Liver Disease &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;(&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;NAFLD&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;)&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;as it &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;relate&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;s&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt; to &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;w&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;estern diet-induced obesity. For this purpose, 21-day-old male Swiss mice were divided into &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;a &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;control group (CG, N=8), &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;which was &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;fed a standard diet, and &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;an &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;obese group (GO, N=16), &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;which was &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;fed a &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;w&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;estern diet, rich in saturated fat and simple carbohydrates, for 12 weeks. In the 11th week, part of the animals in the obese group (N=8) received a daily subcutaneous injection of recombinant human IGF-1 (100碌g/kg/day) &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;during &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;seven consecutive days (GO+IGF-1). &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;Biometric and metabolic parameters, intraperitoneal glucose tolerance test (IGTT), quantitative analysis of liver steatosis, quantitative analysis of collagen in liver and expression of immunoperoxidase of alpha-smooth muscle actin (a-SMA) were &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;analyzed&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;. &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;Our data demonstrated that &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;IGF-1 short-term &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;treatment was able to improve obesity-related biometric and metabolic parameters. In addition, it promoted the recovery of liver parenchyma, &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;thereby &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;reducing steatosis and fibrosis, thus demonstrating an important hepatoprotective action&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW227868565 BCX0&quot;&gt;.&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;EOP SCXW227868565 BCX0&quot; data-ccp-props=&quot;{&amp;quot;201341983&amp;quot;:0,&amp;quot;335551550&amp;quot;:6,&amp;quot;335551620&amp;quot;:6,&amp;quot;335559737&amp;quot;:-3,&amp;quot;335559739&amp;quot;:0,&amp;quot;335559740&amp;quot;:360}&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
ER  -