  TY  - JOUR
AU  - Isabela G. Bristotte, 
AU  - NatÃ¡lia V. S. Daniel, 
AU  - Luciana Pietro, 
PY  - 2023/12/20
Y2  - 2024/10/12
TI  - Prevalence of vitamin D deficiency in children with sickle cell anemia: a systematic review
JF  - Ïã¸ÛÁùºÏ²Ê¿ª½±½á¹û
JA  - BJHBS
VL  - 22
IS  - 2
SE  - Literature Review
DO  - 10.12957/bjhbs.2023.80047
UR  - /bjhbs/article/view/153
SP  - 
AB  - &lt;p&gt;&lt;span class=&quot;TextRun SCXW222966409 BCX0&quot; lang=&quot;EN-US&quot; xml:lang=&quot;EN-US&quot; data-contrast=&quot;auto&quot;&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;Sickle cell anemia is a &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;genetic disease &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;that is &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;highly prevalent in the Brazilian population, &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;especially&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; among&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; black ethnic groups &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;descended &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;from migration&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; of enslaved people from Africa&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;, as well as &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;descendants &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;from the &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;process &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;of &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;miscegenation. &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;The&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; disease &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;is a&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;clinical expression of the homozygosity of the hemoglobin S gene, which may be &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;of&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; genetic and/or hereditary &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;origin&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;, &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;and is &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;caused by the replacement of the normal residue of glutamic acid &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;with&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;the amino acid valine in the sixth position of the polypeptide chains of the beta-globin protein&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;. This process &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;generat&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;es &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;biochemical alteration&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;s&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; in hemoglobin S molecules&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; that &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;polymerize inside the erythrocyte and transform into sickle cell&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;s&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;. &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;L&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;ack of vitamin D may &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;possibly &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;be linked to &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;disease processes, as well as to individuals&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;â€™&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; pain crises. Objectives: To&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;conduct&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; a systematic review &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;in order to &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;analyze &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;the&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; prevalence of vitamin D deficiency in children with sickle cell anemia. Methodology: A systematic review was carried out by &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;means of &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;a &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;search for original articles &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;in the English and Portuguese&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;languages &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;in the &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;following &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;scientific databases: Pubmed, Science Direct, Lilacs and Sciel&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;o&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;. Results: &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;Among&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; 10 articles&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; found&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;, 8 showed &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;a&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;prevalence of vitamin D deficiency (&amp;lt;20 ng/ml)&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;in children with sickle cell anemia. Conclusion: The prevalence of vitamin D deficiency was high in patients with &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;sickle cell&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;disease, so supplementation &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;of this substance &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;may &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;be helpful in&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; treatment&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;s&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; to improve the condition and &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;in &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;prevent&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;ing&lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt; deficiency. However, &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;further&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;studies &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;that target&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;this association and/or intervention are &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;required&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;to &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;obtain&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;more &lt;/span&gt;&lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;practical&lt;/span&gt; &lt;span class=&quot;NormalTextRun SCXW222966409 BCX0&quot;&gt;results.&lt;/span&gt;&lt;/span&gt;&lt;span class=&quot;EOP SCXW222966409 BCX0&quot; data-ccp-props=&quot;{&amp;quot;201341983&amp;quot;:0,&amp;quot;335551550&amp;quot;:6,&amp;quot;335551620&amp;quot;:6,&amp;quot;335559739&amp;quot;:0,&amp;quot;335559740&amp;quot;:360}&quot;&gt;&amp;nbsp;&lt;/span&gt;&lt;/p&gt;
ER  -