TY  - JOUR
AU  - Chantre-Justino, Mariana
AU  - Delmonico, Lucas
AU  - Lage, Claudia
AU  - G. C. Carvalho, Maria
AU  - F. Ornellas, Maria Helena
AU  - Alves, Gilda
PY  - 2022/01/04
Y2  - 2024/10/12
TI  - Tracking the history of circulating nucleic acids for cancer research in Brazil: A systematic review
JF  - 香港六合彩开奖结果
JA  - BJHBS
VL  - 20
IS  - 2
SE  - Original Articles
DO  - 10.12957/bjhbs.2021.63966
UR  - /bjhbs/article/view/36
SP  - 135-143
AB  - <p>Introduction: Circulating nucleic acids can be obtained by minimally invasive procedures based on liquid biopsy, which has emerged as a promising area of investigation for screening and monitoring cancer treatment. Currently, tests based on circulating nucleic acid analysis, specifically cell-free DNA (cfDNA), are commercially available for diagnostic and prognostic investigation of a number of neoplasms. Ob-jective: To describe the research on circulating nucleic acid markers for cancer prospecting in Brazil, since this area has advanced rapidly in recent years. Methods: In this systematic review, we surveyed Brazilian publications in cancer research focused on cfDNA and cfRNA present in different fluids. Both MEDLINE-PUBMED and EMBASE databases were inspected using terms such as 鈥渃irculating nucleic acids鈥�, 鈥渃ancer鈥�, and 鈥淏razil鈥�. Results: The search returned 326 articles, in which 28 Brazilian translational studies were eligible. Different methodologies were reported for different types of cancer, in which cfDNA from plasma was the most investigated biological material. Molecular investigations included quan-tification, somatic mutation, RNA expression, genotyping, microsatellites, blood protein interaction, and methylation. Discrepancies in the regional distribution of the studies were also observed. Conclusion: Studies on circulating nucleic acid markers have advanced significantly in the oncology field, but many others are needed to better address the clinical practice in Brazil.</p>
ER  -